By Rachel Crumpler
Light spotting. Constipation. Feeling tired. Skin losing its glow.
Martha Jean Williams, 57 at the time, dismissed all of it as routine aging.
Months later, in October 2012, she went in for a regular checkup with her doctor.
It turned out that she should have been more worried about the spotting. She had gone through menopause at age 50. In the seven years since she experienced no bleeding at all — until March.
“I remember asking three different women about it because I’d already been through menopause,” Williams said. “They said, ‘Oh, no big deal. I bleed all the time.’ It wasn’t heavy or anything and it wasn’t every day, so I just ignored it.”
When she mentioned the light spotting to her doctor, he had a different reaction — one of concern. He told her to get a biopsy.
The result came back: she had endometrial cancer, also known as uterine cancer.
Martha Jean Williams is an endometrial cancer survivor. She is part of the Endometrial Cancer Action Network for African-Americans where she serves as a board member and member of the group’s research partnerships committee. Credit: Courtesy of Martha Jean Williams
Martha Jean Williams is an endometrial cancer survivor. She is part of the Endometrial Cancer Action Network for African-Americans where she serves as a board member and member of the group’s research partnerships committee. The news was a shock. It was only the third time in her life that she’d been sick beyond a cold. This type of cancer was unfamiliar to her, even though endometrial cancer is the only major cancer type that is increasing in both frequency and mortality.
“I had no information whatsoever, had never had a conversation about uterine cancer,” Williams said. “I don’t know that I had even heard of it before I had it. I had heard of breast cancer and ovarian cancer, but this, no.”
‘Greatest cancer disparity’
Williams, who lives in New Orleans, did not find out about the stark racial disparity in endometrial cancer outcomes — one of the largest disparities for any cancer type — until years later when she joined the Endometrial Cancer Action Network for African-Americans in 2018. ECANA is a national group of patients, doctors, survivors, community advocates and professional leaders committed to the single purpose of improving the lives of Black women affected by endometrial cancer.
Black women die of uterine cancer at twice the rate of white women, and the reasons for the disparity remain unclear.
That’s an unacceptable fact for a group of researchers and clinicians at UNC Lineberger Comprehensive Cancer Center. That’s why they have research underway to investigate many factors such as tumor biology, access to care, and lifestyle and behavior that may play a role in survivorship.
The goal is to acquire vital knowledge that can be used to improve endometrial cancer outcomes and close the racial disparity gap.
“I think that endometrial cancer is probably the greatest cancer disparity in North Carolina, so it’s kind of about time that we paid attention to it now,” said Victoria Bae-Jump, director of UNC Lineberger’s Endometrial Cancer Center of Excellence and a gynecologic oncologist. “It’s on the rise both in frequency and mortality.”
Increasing cases, increasing deaths
In North Carolina, based on preliminary 2020 data, there were 1,706 cases of uterine cancer — an incidence rate of 23.1 per 100,000. The same year, there were 408 deaths with a significant disparity in mortality, with a death rate for white women at 4.0 per 100,000 compared to a rate of 9.7 per 100,000 for all minorities.
Hazel Nichols, an associate professor in the epidemiology department at UNC-Chapel Hill’s Gillings School of Global Public Health who researches cancer, says it’s common for people to be diagnosed and say they have never heard of endometrial cancer, also known as uterine cancer, prior to the diagnosis. Nichols said this cancer type hasn’t gotten the national and local attention it deserves.
After all, it’s a cancer everyone with a uterus should know about.
Currently, endometrial cancer is the fourth most common cancer among women in the United States. But with cases on the rise, cancer of the uterus is expected to pass colorectal cancer by 2040 as the third most common cancer among women.
Facts About Endometrial (Uterine) Cancer
In 2022, an estimated 65,950 new cases of uterine cancer will be diagnosed in the U.S. and 12,550 women are expected to die from it, according to the American Cancer Society.Among all women, uterine cancer mortality rates have increased by 1.8 percent per year from 2010 to 2017.Endometrial cancer mainly affects post-menopausal women. It’s uncommon in women under the age of 45.Obesity is a strong risk factor for endometrial cancer. The cancer is twice as common in overweight women and more than three times as common in obese women.Abnormal vaginal bleeding — either after menopause or between periods — is the most frequent symptom of endometrial cancer, along with pelvic pain.
For many other cancers, researchers have been successful in seeing overall declines in incidence and mortality rates as well as in reducing the gap between Black and white patient outcomes, said Nichols. Yet she said these improvements have not occurred with endometrial cancer primarily because it’s been underfunded and understudied.
Uterine cancer has consistently ranked at the bottom of research funding by cancer type. The National Cancer Institute reported spending an estimated $13.6 million on uterine cancer research in 2020, a drop from $18 million in 2019. The only cancer type with less NCI funding in 2020 was stomach cancer, which received $10.6 million. In comparison, breast cancer received more than half a billion dollars in research funding.
Last November, UNC Lineberger Comprehensive Cancer Center launched the Endometrial Cancer Center of Excellence to increase its focus on advancing scientific understanding of the causes, prevention and treatment of endometrial cancer.
“Every year we have more deaths, we have more women diagnosed, and we don’t really completely understand why,” said Bae-Jump, the center’s director who was elected co-chair of the National Cancer Institute Gynecologic Cancers Steering Committee’s Uterine Task Force in May.
Looking for answers
One ambitious statewide, population-based study, the Carolina Endometrial Cancer Study, seeks to find answers, and it’s casting a wide net to do so.
Researchers are seeking to enroll about 1,800 adults ages 20-80 living in any of North Carolina’s counties at the time of their recent first diagnosis of endometrial cancer to learn why people have different outcomes and experiences. Women of all races will be enrolled, but the study has a particular target of enrolling at least 500 Black women.
Bae-Jump, a study investigator, said this study is the largest on endometrial cancer in the South, one of the first studies to include significant numbers of Black women and the first to look at different subtypes of endometrial cancer.
“The overarching goal is to address why are endometrial cancer outcomes worsening? And then why is that worsening particularly striking for Black women?” Bae-Jump said.
Past studies have identified potential drivers of the racial disparity, including that Black women are more likely to be diagnosed with advanced-stage cancer, have a greater prevalence of health conditions and are less likely to undergo surgery to treat their cancer.
Bae-Jump suspects the answer will be multi-pronged. That’s why the study is examining both biological factors and social determinants of health in its search for answers.
“We’re trying to bring to bear all the different disciplines of public health and medicine so that we get this fuller view of the contributors to an endometrial cancer diagnosis and survivorship,” Nichols, one of the study’s principal investigators, said.
The first endometrial cancer patient was enrolled in the study in February 2021, Bae-Jump said, and she expects it to take four to five years to enroll the target number of study participants. Investigators identify potential study participants from the North Carolina Central Cancer Registry.
Participants are first asked to complete a thorough survey that includes questions about family history, medical history, lifestyle, treatment and access to care.
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“We’re asking not only the questions that the scientific community thinks are important but that the women who are living with this diagnosis think are important,” Nichols said.
Participants are also asked to provide consent for researchers to obtain their medical records, a sample of stored tissue from diagnosis or treatment and a saliva sample through a self-collection kit. With permission, study staff will follow up with participants annually for about five years to ask about treatment status and quality of life.
Women can participate in all aspects of the study or can choose to participate in just select parts. Financial compensation will be provided for completing parts of the study.
This study is modeled after UNC Lineberger’s Carolina Breast Cancer Study, which is a population-based study that began in 1993 and continues today, producing more than 200 published research findings over that time. The study examines how the causes, treatment and long-term outcomes of breast cancer differ between Black and white women.
UNC Lineberger is also embarking on a study led by Bae-Jump looking at the impact of race and the microbiome — the microorganisms such as bacteria, fungi and viruses living in a person — on the progression and treatment of endometrial cancer. The gut microbiome is known to affect biologic pathways for both obesity and cancer, but this research seeks to determine whether there is an inter-relationship between the gut and uterine microbiome, racial disparities, obesity and endometrial cancer.
Potential impact
It’s too early to tell what the results of the Carolina Endometrial Cancer Study will be but those involved are hopeful it will lead to long overdue progress.
“We’re very ambitious,” Nichols said. “We’re hoping that the information we learn from women who are able to contribute samples of their individual cancer tumors will help drive new treatments. We’re hoping that the information we learn about experiences navigating the health care system will help us design better ways for patients to navigate the health care system.
“We’re also hoping that some of the survey data will give us information that we can bring directly back to participants to see if there are things that they can choose to do in their own lives, whether that’s getting involved with specific organizations or starting walking regimens or other things that have helped other women in North Carolina.”
And progress is all that Williams, an endometrial cancer survivor, wants.
“I was like speechless thinking, could I have not even been on this journey had we had better information?” Williams said.
She can’t help but think, if there had been better information, would she have taken her light spotting more seriously? Would she have had a hysterectomy sooner? Would there have been a need for the six weeks of radiation and months of chemotherapy — treatments that nearly killed her?
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<h1>Uterine cancer cases rising, outcomes worsening especially for Black women</h1>
<p class=”byline”>by Rachel Crumpler, North Carolina Health News <br />July 26, 2022</p>
<br />
<h4 id=”h-by-rachel-crumpler”><strong>By Rachel Crumpler</strong></h4>
<p>Light spotting. Constipation. Feeling tired. Skin losing its glow.</p>
<p>Martha Jean Williams, 57 at the time, dismissed all of it as routine aging. </p>
<p>Months later, in October 2012, she went in for a regular checkup with her doctor. </p>
<p>It turned out that she should have been more worried about the spotting. She had gone through menopause at age 50. In the seven years since she experienced no bleeding at all — until March. </p>
<figure class=”wp-block-image aligncenter size-full is-resized”><a href=”https://www.northcarolinahealthnews.org/donate/”><img src=”https://www.northcarolinahealthnews.org/wp-content/uploads/2021/04/COVID-Donate-Ad-NEW-April-2021.png” alt=”” class=”wp-image-33559″ width=”590″ height=”177″ /></a></figure>
<p>“I remember asking three different women about it because I’d already been through menopause,” Williams said. “They said, ‘Oh, no big deal. I bleed all the time.’ It wasn’t heavy or anything and it wasn’t every day, so I just ignored it.”</p>
<p>When she mentioned the light spotting to her doctor, he had a different reaction — one of concern. He told her to get a biopsy. </p>
<p>The result came back: she had endometrial cancer, also known as uterine cancer.</p>
<figure class=”wp-block-image alignright size-large”><img src=”https://www.northcarolinahealthnews.org/wp-content/uploads/2022/07/MJW-headshot_0-450×341.png” alt=”Headshot of Martha Jean Williams, an endometrial cancer survivor” class=”wp-image-40377″ /><figcaption>Martha Jean Williams is an endometrial cancer survivor. She is part of the Endometrial Cancer Action Network for African-Americans where she serves as a board member and member of the group’s research partnerships committee. </figcaption></figure>
<p>The news was a shock. It was only the third time in her life that she’d been sick beyond a cold. This type of cancer was unfamiliar to her, even though endometrial cancer is the only major cancer type that is increasing in both frequency and mortality.</p>
<p>“I had no information whatsoever, had never had a conversation about uterine cancer,” Williams said. “I don’t know that I had even heard of it before I had it. I had heard of breast cancer and ovarian cancer, but this, no.” </p>
<h4><strong>‘Greatest cancer disparity’</strong></h4>
<p>Williams, who lives in New Orleans, did not find out about the stark racial disparity in endometrial cancer outcomes — one of the largest disparities for any cancer type — until years later when she joined the <a href=”https://ecanawomen.org/” target=”_blank” rel=”noreferrer noopener”>Endometrial Cancer Action Network for African-Americans</a> in 2018. ECANA is a national group of patients, doctors, survivors, community advocates and professional leaders committed to the single purpose of improving the lives of Black women affected by endometrial cancer.</p>
<p>Black women die of uterine cancer at <a href=”https://www.ncbi.nlm.nih.gov/books/NBK525981/#:~:text=The%20prevalence%20of%20endometrial%20cancer,years%20(median%2062%20years).” target=”_blank” rel=”noreferrer noopener”>twice the rate</a> of white women, and the reasons for the disparity remain unclear. </p>
<p>That’s an unacceptable fact for a group of researchers and clinicians at <a href=”https://unclineberger.org/” target=”_blank” rel=”noreferrer noopener”>UNC Lineberger Comprehensive Cancer Center</a>. That’s why they have research underway to investigate many factors such as tumor biology, access to care, and lifestyle and behavior that may play a role in survivorship.</p>
<p>The goal is to acquire vital knowledge that can be used to improve endometrial cancer outcomes and close the racial disparity gap.</p>
<p>“I think that endometrial cancer is probably the greatest cancer disparity in North Carolina, so it’s kind of about time that we paid attention to it now,” said <a href=”https://unclineberger.org/directory/victoria-l-bae-jump/” target=”_blank” rel=”noreferrer noopener”>Victoria Bae-Jump</a>, director of UNC Lineberger’s <a href=”https://unclineberger.org/endometrial-cancer-center-of-excellence/” target=”_blank” rel=”noreferrer noopener”>Endometrial Cancer Center of Excellence</a> and a gynecologic oncologist. “It’s on the rise both in frequency and mortality.” </p>
<h4><strong>Increasing cases, increasing deaths</strong></h4>
<p>In North Carolina, based on <a href=”https://schs.dph.ncdhhs.gov/schs/CCR/incidence/2020/2020-PreliminaryIncidenceRatesFinal-Race.pdf” target=”_blank” rel=”noreferrer noopener”>preliminary 2020 data</a>, there were 1,706 cases of uterine cancer — an incidence rate of 23.1 per 100,000. The same year, there were 408 deaths with a significant <a href=”https://schs.dph.ncdhhs.gov/schs/CCR/2020-MortalityRatesFinalForWebsite-Race.pdf” target=”_blank” rel=”noreferrer noopener”>disparity in mortality</a>, with a death rate for white women at 4.0 per 100,000 compared to a rate of 9.7 per 100,000 for all minorities.</p>
<p><a href=”https://sph.unc.edu/adv_profile/hazel-b-nichols-phd/” target=”_blank” rel=”noreferrer noopener”>Hazel Nichols</a>, an associate professor in the epidemiology department at UNC-Chapel Hill’s <a href=”https://sph.unc.edu/” target=”_blank” rel=”noreferrer noopener”>Gillings School of Global Public Health</a> who researches cancer, says it’s common for people to be diagnosed and say they have never heard of endometrial cancer, also known as uterine cancer, prior to the diagnosis. Nichols said this cancer type hasn’t gotten the national and local attention it deserves.</p>
<p>After all, it’s a cancer everyone with a uterus should know about. </p>
<p>Currently, endometrial cancer is the fourth most common cancer among women in the United States. But with cases on the rise, cancer of the uterus is expected to pass colorectal cancer by 2040 as the <a href=”https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2778204″ target=”_blank” rel=”noreferrer noopener”>third most common cancer among women</a>.</p>
<div class=”wp-block-group has-secondary-background-color has-background”>
<p><strong>Facts About Endometrial (Uterine) Cancer</strong></p>
<ul>
<li>In 2022, an estimated 65,950 new cases of uterine cancer will be diagnosed in the U.S. and 12,550 women are expected to die from it, according to the <a href=”https://www.cancer.org/cancer/endometrial-cancer/about/key-statistics.html”>American Cancer Society</a>.</li>
<li>Among all women, uterine cancer <a href=”https://jamanetwork.com/journals/jamaoncology/article-abstract/2792010#:~:text=In%20a%202019%20analysis%20of,and%20non%2DHispanic%20Black%20women.”>mortality rates have increased by 1.8 percent</a> per year from 2010 to 2017.</li>
<li>Endometrial cancer mainly affects post-menopausal women. It’s uncommon in women under the age of 45.</li>
<li>Obesity is a strong <a href=”https://www.cancer.org/cancer/endometrial-cancer/causes-risks-prevention/risk-factors.html#:~:text=more%20detail%20below.-,Obesity,(called%20androgens)%20into%20estrogens.”>risk factor</a> for endometrial cancer. The cancer is twice as common in overweight women and more than three times as common in obese women.</li>
<li>Abnormal vaginal bleeding — either after menopause or between periods — is the most frequent <a href=”https://www.mayoclinic.org/diseases-conditions/endometrial-cancer/symptoms-causes/syc-20352461″ target=”_blank” rel=”noreferrer noopener”>symptom</a> of endometrial cancer, along with pelvic pain.</li>
</ul></div>
<p>For many other cancers, researchers have been successful in seeing overall declines in incidence and mortality rates as well as in reducing the gap between Black and white patient outcomes, said Nichols. Yet she said these improvements have not occurred with endometrial cancer primarily because it’s been underfunded and understudied.</p>
<p>Uterine cancer has consistently ranked at the <a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519051/” target=”_blank” rel=”noreferrer noopener”>bottom of research funding</a> by cancer type. <a href=”https://www.cancer.gov/about-nci” target=”_blank” rel=”noreferrer noopener”>The National Cancer Institute</a> reported <a href=”https://www.cancer.gov/about-nci/budget/fact-book/data/research-funding” target=”_blank” rel=”noreferrer noopener”>spending</a> an estimated $13.6 million on uterine cancer research in 2020, a drop from $18 million in 2019. The only cancer type with less NCI funding in 2020 was stomach cancer, which received $10.6 million. In comparison, breast cancer received more than half a billion dollars in research funding.</p>
<figure class=”wp-block-embed aligncenter is-type-wp-embed is-provider-datawrapper wp-block-embed-datawrapper”>
<div class=”wp-block-embed__wrapper”>
</div>
</figure>
<p>Last November, UNC Lineberger Comprehensive Cancer Center <a href=”https://unclineberger.org/news/endometrial-cancer-center-of-excellence-focused-on-advancing-research-and-care-eliminating-disparities/” target=”_blank” rel=”noreferrer noopener”>launched the Endometrial Cancer Center of Excellence</a> to increase its focus on advancing scientific understanding of the causes, prevention and treatment of endometrial cancer. </p>
<p>“Every year we have more deaths, we have more women diagnosed, and we don’t really completely understand why,” said Bae-Jump, the center’s director who was <a href=”https://unclineberger.org/news/bae-jump-elected-co-chair-of-nci-uterine-task-force/” target=”_blank” rel=”noreferrer noopener”>elected co-chair</a> of the National Cancer Institute <a href=”https://www.cancer.gov/about-nci/organization/ccct/steering-committees/nctn/gynecologic” target=”_blank” rel=”noreferrer noopener”>Gynecologic Cancers Steering Committee’</a>s Uterine Task Force in May.</p>
<h4><strong>Looking for answers</strong></h4>
<p>One ambitious statewide, population-based study, the <a href=”https://unclineberger.org/cecs/” target=”_blank” rel=”noreferrer noopener”>Carolina Endometrial Cancer Study</a>, seeks to find answers, and it’s casting a wide net to do so.</p>
<p>Researchers are seeking to enroll about 1,800 adults ages 20-80 living in any of North Carolina’s counties at the time of their recent first diagnosis of endometrial cancer to learn why people have different outcomes and experiences. Women of all races will be enrolled, but the study has a particular target of enrolling at least 500 Black women.</p>
<p>Bae-Jump, a study investigator, said this study is the largest on endometrial cancer in the South, one of the first studies to include significant numbers of Black women and the first to look at different subtypes of endometrial cancer.</p>
<p>“The overarching goal is to address why are endometrial cancer outcomes worsening? And then why is that worsening particularly striking for Black women?” Bae-Jump said.</p>
<p>Past studies have identified potential drivers of the racial disparity, including that Black women are more likely to be diagnosed with advanced-stage cancer, have a greater prevalence of health conditions and are less likely to undergo surgery to treat their cancer.</p>
<p>Bae-Jump suspects the answer will be multi-pronged. That’s why the study is examining both biological factors and social determinants of health in its search for answers. </p>
<p>“We’re trying to bring to bear all the different disciplines of public health and medicine so that we get this fuller view of the contributors to an endometrial cancer diagnosis and survivorship,” Nichols, one of the study’s <a href=”https://unclineberger.org/cecs/meet-the-staff/” target=”_blank” rel=”noreferrer noopener”>principal investigators</a>, said.</p>
<p>The first endometrial cancer patient was enrolled in the study in February 2021, Bae-Jump said, and she expects it to take four to five years to enroll the target number of study participants. Investigators identify potential study participants from the <a href=”https://schs.dph.ncdhhs.gov/units/ccr/” target=”_blank” rel=”noreferrer noopener”>North Carolina Central Cancer Registry</a>.</p>
<p>Participants are first asked to complete a thorough survey that includes questions about family history, medical history, lifestyle, treatment and access to care. </p>
<p>“We’re asking not only the questions that the scientific community thinks are important but that the women who are living with this diagnosis think are important,” Nichols said.</p>
<p>Participants are also asked to provide consent for researchers to obtain their medical records, a sample of stored tissue from diagnosis or treatment and a saliva sample through a self-collection kit. With permission, study staff will follow up with participants annually for about five years to ask about treatment status and quality of life. </p>
<p>Women can participate in all aspects of the study or can choose to participate in just select parts. Financial compensation will be provided for completing parts of the study. </p>
<p>This study is modeled after UNC Lineberger’s <a href=”https://unclineberger.org/cbcs/” target=”_blank” rel=”noreferrer noopener”>Carolina Breast Cancer Study</a>, which is a population-based study that began in 1993 and continues today, producing more than 200 published research findings over that time. The study examines how the causes, treatment and long-term outcomes of breast cancer differ between Black and white women.</p>
<p>UNC Lineberger is also embarking on a <a href=”https://unclineberger.org/trend/about-trend/project-2/” target=”_blank” rel=”noreferrer noopener”>study</a> led by Bae-Jump looking at the impact of race and the microbiome — the microorganisms such as bacteria, fungi and viruses living in a person — on the progression and treatment of endometrial cancer. The gut microbiome is known to affect biologic pathways for both obesity and cancer, but this research seeks to determine whether there is an inter-relationship between the gut and uterine microbiome, racial disparities, obesity and endometrial cancer.</p>
<div class=”wp-block-group has-secondary-background-color has-background”>
<div class=”wp-block-group has-light-gray-color has-secondary-background-color has-text-color has-background”> </div>
</p></div>
<h4><strong>Potential impact</strong></h4>
<p>It’s too early to tell what the results of the Carolina Endometrial Cancer Study will be but those involved are hopeful it will lead to long overdue progress. </p>
<p>“We’re very ambitious,” Nichols said. “We’re hoping that the information we learn from women who are able to contribute samples of their individual cancer tumors will help drive new treatments. We’re hoping that the information we learn about experiences navigating the health care system will help us design better ways for patients to navigate the health care system. </p>
<p>“We’re also hoping that some of the survey data will give us information that we can bring directly back to participants to see if there are things that they can choose to do in their own lives, whether that’s getting involved with specific organizations or starting walking regimens or other things that have helped other women in North Carolina.”</p>
<p>And progress is all that Williams, an endometrial cancer survivor, wants. </p>
<p><strong>“</strong>I was like speechless thinking, could I have not even been on this journey had we had better information?” Williams said.</p>
<p>She can’t help but think, if there had been better information, would she have taken her light spotting more seriously? Would she have had a hysterectomy sooner? Would there have been a need for the six weeks of radiation and months of chemotherapy — treatments that nearly killed her? </p>
This <a target=”_blank” href=”https://www.northcarolinahealthnews.org/2022/07/26/stark-racial-disparity-in-endometrial-cancer-outcomes/”>article</a> first appeared on <a target=”_blank” href=”https://www.northcarolinahealthnews.org”>North Carolina Health News</a> and is republished here under a Creative Commons license.<img src=”https://i0.wp.com/www.northcarolinahealthnews.org/wp-content/uploads/2021/10/cropped-favicon02.jpg?fit=150%2C150&ssl=1″ style=”width:1em;height:1em;margin-left:10px;”><img id=”republication-tracker-tool-source” src=”https://www.northcarolinahealthnews.org/?republication-pixel=true&post=40371&ga=UA-28368570-1″ style=”width:1px;height:1px;”>
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