It’s time for the NFL Week 5 picks and predictions, and there are a litany of terrific games to break down for the weekend.
As always, all lines are provided by our partners at WynnBet.
Matchup
Indianapolis Colts
1-2-1 
Denver Broncos
2-2
Thursday, Oct. 6
8:20 p.m. ET
Take both these teams — and their quarterbacks — to the glue factory. It’s going to be a battle of wills … for the teams and fans.
Pick: Denver 19, Indianapolis 17
Matchup
Green Bay Packers
3-1 
New York Giants
3-1
Sunday, Oct. 9
9:30 p.m. ET
The Giants are surprising early, while the Packers are underwhelming. Yet both are 3-1, largely because Green Bay is so much more talented than most. Expect the Packers to prevail.
Pick: Green Bay 27, New York 20
Matchup
Atlanta Falcons
2-2 
Tampa Bay Buccaneers
2-2
Tough to see the Buccaneers losing three straight games, let alone at home. Tom Brady will significantly outplay Marcus Mariota, and that’ll be the chief difference.
Pick: Tampa Bay 26, Atlanta 13
Matchup
Chicago Bears
2-2 
Minnesota Vikings
3-1
The Vikings have a propensity to make games like this interesting, but the Bears don’t have enough firepower to win.
Pick: Minnesota 28, Chicago 15
Matchup
Detroit Lions
1-3 
New England Patriots
1-3
Points will be scored. The question is who is under center for the Patriots, and can the Lions get a few key stops?
Pick: New England 30, Detroit 28
Matchup
Houston Texans
0-3-1 
Jacksonville Jaguars
2-2
The Jaguars are showing real progress. The Texans are not. Jacksonville should handle business at home against Houston.
Pick: Jacksonville 29, Houston 17
Matchup
Los Angeles Chargers
2-2 
Cleveland Browns
2-2
Toughest game to pick this week. Who the hell knows? Nick Chubb might run for 200 yards.
Pick: Cleveland 24, Los Angeles 23
Matchup
Miami Dolphins
3-1 
New York Jets
2-2
How much of a difference is there between Teddy Bridgewater and Tua Tagovailoa? We’re about to find out.
Pick: Miami 25, New York 23
Matchup
Pittsburgh Steelers
1-3 
Buffalo Bills
3-1
This is going to be a ritualistic killing.
Pick: Buffalo 30, Pittsburgh 9
Matchup
Seattle Seahawks
2-2 
New Orleans Saints
1-3
Why are the Saints favored by 5.5 points? They’ve been awful every game this season, while the Seahawks are 2-2 and playing really solid offense.
Pick: Seattle 24, New Orleans 22
Matchup
Tennessee Titans
2-2 
Washington Commanders
1-3
Tennessee is back in business after winning the last two weeks, while Washington has lost three straight. Should be a close game, coming down to who makes a big mistake or two.
Pick: Tennessee 24, Washington 21
